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Sezary Syndrome - Symptoms & Treatment


Sezary syndrome is a disease in which certain cells of the lymph system (called T-lymphocytes) become cancer (malignant) and affect the skin. In the Sézary syndrome, skin all over the body is reddened, itchy, peeling, and painful. There may also be patches, plaques, or tumors on the skin. Sezary syndrome is relatively rare, affecting about one in one million people. Sezary syndrome is an advanced form of mycosis fungoides. There are no known causes of Sezary syndrome. It can affect many organs. In early stage disease, the skin is the only organ affected; however, later stage disease can affect other organ systems. There are many different types of primary cutaneous lymphomas but they can be broadly divided into two categories, cutaneous T-cell lymphomas and cutaneous B-cell lymphomas. It is is characterized by skin abnormalities, extreme itching, enlarged lymph glands, and abnormal blood cells. Men appear to be affected more often than women, and black males appear to be at higher risk of developing the syndrome than white males. There are multiple therapies for Sézary syndrome. However, unless the disease is in an early stage, the chances for a complete cure are small.

Causes of Sezary syndrome

The common causes and risk factor's of Sezary syndrome include the following:

  • The exect cause of sezary syndrome is unknown.
  • Genetic predisposition is the main cause.
  • Long-term exposure to industrial or environmental metals.
  • Exposure to certain chemicals.

Symptoms of Sezary syndrome

Some sign and symptoms related to Sezary syndrome are as follows:

  • The skin may itch, and dry.
  • Harmless swelling.
  • Dark patches may develop on the skin.
  • Red rash on the skin.
  • Hair loss, in the areas of and surrounding the patches.
  • Skin changes.
  • Enlarged lymph glands in the neck.

Treatment of Sezary syndrome

Here is list of the methods for treating Sezary syndrome:

  • Chemotherapy uses drugs to kill cancer cells. Chemotherapy may be taken by pill, or it may be put into the body by a needle in a vein or muscle.
  • Radiation therapy uses high-energy rays to kill cancer cells and shrink tumors.
  • In cutaneous T-cell lymphoma, special rays of tiny particles called electrons are commonly used to treat all of the skin.
  • Oral retinoids may be used.
  • Phototherapy uses light to kill cancer cells. In one type of phototherapy, called PUVA therapy, a patient will receive a drug called psoralen, and then ultraviolet A light will be shone on the skin.

 

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