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Chronic Lupus Panniculitis - Symptoms & Treatment


Chronic lupus panniculitis, or lupus profundus, is a variant of lupus erythematosus that primarily affects subcutaneous fat. Chronic lupus panniculitis may occur in patients with systemic lupus erythematosu. Some patients also have the lesions of subacute cutaneous lupus erythematosus, and some may have a malar rash. Lesions may be tender and painful and frequently heal with atrophy and scars. The lesions are self-limited and resolve completely. Often there are associated arthralgias, malaise, fever, chills, and leukocytosis. It may occur at any age but most often occurs in persons aged 20-40 years. The mean age is approximately 38 years. In 70 percent of patients with lupus panniculitis there will be either preceding, subsequent, or concomitant lesions of discoid lupus erythematosus. In 70 percent of patients with lupus panniculitis there will be either preceding, subsequent, or concomitant lesions of discoid lupus erythematosus. Large vessel vasculitides such as polyarteritis nodosa are a common cause of such changes, usually a lobular pattern. Necrobiosis lipoidica and scleroderma may cause a secondary septal panniculitis. The patient's symptoms improved in that the breast mass decreased, and she experienced some relief of pain. Chronic lupus panniculitis is characterized by deep subcutaneous nodules, most commonly localized on the upper limbs and face. Lupus panniculitis is a chronic condition that often involves persistent lesions that subsequently heal with disfigurement. Lupus panniculitis often responds to treatment with antimalarials, such as hydroxychloroquine.

Causes of Chronic lupus panniculitis

The common causes and risk factor's of Chronic lupus panniculitis include the following:

  • The exect cause of Chronic lupus panniculitis is unknown.
  • Some genetic factors.
  • Chronic lupus panniculitis may occur in patients with systemic lupus erythematosu.
  • Necrobiosis lipoidica and scleroderma.
  • Large vessel vasculitides such as polyarteritis nodosa.

Symptoms of Chronic lupus panniculitis

Some sign and symptoms related to Chronic lupus panniculitis are as follows:

  • Red raised lesions.
  • Abdominal pain.
  • Mild pruritus or occasional pain within the lesions.
  • Fever and hives.
  • Headache.
  • Loss of appetite.
  • Chest pain.
  • Lesions may be tender and frequently heal with atrophy and scars.
  • Shortness of breath.
  • Deep subcutaneous nodules, most commonly localized on the upper limbs and face.

Treatment of Chronic lupus panniculitis

Here is list of the methods for treating Chronic lupus panniculitis:

  • Chronic lupus panniculitis often responds to treatment with antimalarials, such as hydroxychloroquine
  • Cosmetic measures, such as cover-up makeup or wigs, may be suggested for appropriately selected patients.
  • Treatment with intralesional steroids may be effective.
  • Some cases respond to a combination of antimalarials (for example, hydroxychloroquine 200 mg and quinacrine 100 mg daily) when monotherapy is ineffective.
  • Laser therapy may be useful for lesions with prominent telangiectases.

 

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